Theoretical basis of BNCT

BNCT is based on the particular ability of Boron atoms to react with neutrons. In practice BNCT treatment begins by giving carrier substance as a 2-hour infusion into the patient’s peripheral vein. The function of the carrier substance is to transport boron into tumour cells. After that the tumour is irradiated with low energy neutrons which react with boron atoms. As a result of this reaction, strong local radiation will be formed inside the tumour cells. This local radiation destroys the tumour cells, and the effectiveness of treatment is dependent on the boron content of the tumour cells.

 BNCT differs significantly from conventional radiation therapies:

• BNCT is biologically targeted to tumour
• Then radiation used is produced inside the tumour cells (the range of radiation is about a cell in diameter)

The advantages of BNCT:

• BNCT is a single session therapy; on some occasions the treatment is given twice
• The amount of radiation to healthy tissue is minimized due to biological targeting
• BNCT can be used to treat radiation resistant tumours when conventional radiation therapy is ineffective or it cannot be given
• BNCT treatment can be given even after a full dose of conventional radiation therapy